Attanasio G, Quaranta N, Sallustio V
Dept. of Otolaryngology, University "La Sapienza", Italy.
Scand Audiol Suppl. 1998;48:45-52.
Recent investigations have demonstrated that in animal models repeated exposures to mid-intensity noise induce a progressive reduction of the temporary threshold shift (TTS) following the exposures. This phenomenon is named "conditioning" and it is actually able to reduce the permanent threshold shift (PTS) following exposure to high intensity noise; this finding is named "toughening". In the present work the fundamental steps of the research concerning the toughening are reviewed and the biological mechanisms supposed to be underlying this phenomenon discussed. The few preliminary results of the studies on humans are also reported.
最近的研究表明，在动物模型中，反复暴露于中等强度噪声会导致暴露后暂时性阈移（TTS）逐渐降低。这种现象被称为“适应”，实际上它能够降低暴露于高强度噪声后的永久性阈移（PTS）；这一发现被称为“强化”。在本研究中，回顾了有关强化研究的基本步骤，并讨论了该现象背后可能的生物学机制。还报告了关于人类研究的一些初步结果。
