胆红素动力学的扩展模型：喂养、禁食及苯巴比妥对吉尔伯特综合征的影响 - Suppr

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An expanded model of bilirubin kinetics: effect of feeding, fasting, and phenobarbital in Gilbert's syndrome.

作者信息

Kirshenbaum G, Shames D M, Schmid R

出版信息

J Pharmacokinet Biopharm. 1976 Apr;4(2):115-55. doi: 10.1007/BF01086150.

DOI:10.1007/BF01086150

PMID:950587

Abstract

摘要

相似文献

An expanded model of bilirubin kinetics: effect of feeding, fasting, and phenobarbital in Gilbert's syndrome.胆红素动力学的扩展模型：喂养、禁食及苯巴比妥对吉尔伯特综合征的影响

J Pharmacokinet Biopharm. 1976 Apr;4(2):115-55. doi: 10.1007/BF01086150.

Definition of a conjugation of dysfunction in Gilbert's syndrome: studies of the handling of bilirubin loads and of the pattern of bilirubin conjugates secreted in bile.吉尔伯特综合征中功能障碍结合的定义：胆红素负荷处理及胆汁中分泌的胆红素结合物模式的研究

Clin Sci Mol Med. 1978 Jul;55(1):63-71. doi: 10.1042/cs0550063.

Gilbert's syndrome and drug metabolism.吉尔伯特综合征与药物代谢。

Clin Pharmacokinet. 1979 May-Jun;4(3):223-32. doi: 10.2165/00003088-197904030-00004.

[Kinetics of the disappearance of bilirubin in Gilbert's syndrome. Further case studies].[吉尔伯特综合征中胆红素消失的动力学。更多病例研究]

Quad Sclavo Diagn. 1981 Mar;17(1):54-60.

Modeling, identification and parameter estimation of bilirubin kinetics in normal, hemolytic and Gilbert's states.正常、溶血和吉尔伯特综合征状态下胆红素动力学的建模、识别与参数估计

Comput Biomed Res. 1975 Dec;8(6):522-37. doi: 10.1016/0010-4809(75)90024-5.

[Kinetic study of unconjugated bilirubin before and after phenobarbital treatment of 10 patients with Gilbert's syndrome].[苯巴比妥治疗10例吉尔伯特综合征患者前后非结合胆红素的动力学研究]

Minerva Dietol Gastroenterol. 1984 Jan-Mar;30(1):31-5.

Effects of phenobarbital on unconjugated bilirubin clearance, gamma-glutamyltranspeptidase and urinary d-glucaric acid in patients with Gilbert's syndrome.

Hepatogastroenterology. 1982 Dec;29(6):252-5.

Studies on heterogeneity of bilirubin in Gilbert's syndrom using mass spectrometry.

Jinrui Idengaku Zasshi. 1974 Jun;19(1):55-6.

Gilbert's syndrome--more questions than answers.

Lancet. 1987 May 9;1(8541):1071.

Comparison of in-vivo and in-vitro drug metabolism in patients with Gilbert's syndrome.吉尔伯特综合征患者体内和体外药物代谢的比较。

J Assoc Physicians India. 1982 Jun;30(6):357-9.

引用本文的文献

Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.内源性肝血红素通过不产生一氧化碳的途径进行降解。对正常大鼠肝脏和原代肝细胞培养的研究。

J Clin Invest. 1980 May;65(5):1135-40. doi: 10.1172/JCI109767.

Bilirubin kinetics in intact rats and isolated perfused liver. Evidence for hepatic deconjugation of bilirubin glucuronides.完整大鼠和离体灌注肝脏中的胆红素动力学。胆红素葡糖醛酸酯肝去结合的证据。

J Clin Invest. 1981 Apr;67(4):1003-15. doi: 10.1172/jci110111.

Hepatic disposition and biliary excretion of bilirubin and bilirubin glucuronides in intact rats. Differential processing of pigments derived from intra- and extrahepatic sources.完整大鼠体内胆红素及胆红素葡萄糖醛酸苷的肝脏处置和胆汁排泄。肝内和肝外来源色素的差异处理。

J Clin Invest. 1987 Apr;79(4):1172-80. doi: 10.1172/JCI112934.

The micellar sink: a quantitative assessment of the association of organic anions with mixed micelles and other macromolecular aggregates in rat bile.胶束池：大鼠胆汁中有机阴离子与混合胶束及其他大分子聚集体结合的定量评估

J Clin Invest. 1978 Dec;62(6):1122-31. doi: 10.1172/JCI109231.

The mechanism of haem catabolism. Bilirubin formation in living rats by [18O]oxygen labelling.血红素分解代谢的机制。通过[18O]氧标记在活体大鼠中形成胆红素。

Biochem J. 1978 Feb 15;170(2):297-311. doi: 10.1042/bj1700297.

Role of ineffective erythropoiesis in anaemia of RA.无效红细胞生成在类风湿关节炎贫血中的作用。

Ann Rheum Dis. 1977 Dec;36(6):592-3. doi: 10.1136/ard.36.6.592.

Twenty-five years of progress in bilirubin metabolism (1952-77).胆红素代谢25年的进展（1952 - 1977年）

Gut. 1978 Jun;19(6):481-91. doi: 10.1136/gut.19.6.481.

New insights into the classification and mechanisms of hereditary, chronic, non-haemolytic hyperbilirubinaemias.遗传性慢性非溶血性高胆红素血症的分类及发病机制新见解

Gut. 1978 Jun;19(6):474-80. doi: 10.1136/gut.19.6.474.

本文引用的文献

On the origin of bile pigment in normal man.关于正常人胆汁色素的来源

J Biol Chem. 1950 May;184(1):351-8.

Studies in congenital porphyria. 2. Incorporation of 15N in the stercobilin in the normal and in the porphyric.先天性卟啉症的研究。2. 正常人和卟啉症患者粪便中粪胆素的15N掺入情况。

Biochem J. 1950 Jun-Jul;47(1):87-92. doi: 10.1042/bj0470087.

Jaundice in thalassemia minor: a consequence of "ineffective erythropoiesis".轻型地中海贫血中的黄疸：“无效红细胞生成”的结果。

N Engl J Med. 1962 Sep 13;267:523-9. doi: 10.1056/NEJM196209132671101.

An evaluation of factors influencing the discriminative effectiveness of a group of liver function tests. II. Normal limits of eleven representative hepatic tests.一组肝功能试验鉴别效能的影响因素评估。II. 十一项代表性肝脏试验的正常范围

Gastroenterology. 1955 May;28(5):766-84.

THE CONVERSION OF HEMATIN TO BILE PIGMENT IN THE RAT.大鼠体内血红素向胆色素的转化

J Lab Clin Med. 1965 May;65:817-24.

THE QUANTITATIVE HISTOCHEMISTRY OF THE NORMAL HUMAN LIVER LOBULE.正常人体肝小叶的定量组织化学

J Lab Clin Med. 1965 Feb;65:248-56.

THE EARLY APPEARING BILIRUBIN: EVIDENCE FOR TWO COMPONENTS.早期出现的胆红素：两种成分的证据。

J Clin Invest. 1965 Jan;44(1):31-41. doi: 10.1172/JCI105124.

INTRACELLULAR DISTRIBUTION OF TRITIATED BILIRUBIN DURING HEPATIC UPTAKE AND EXCRETION.肝摄取和排泄过程中氚标记胆红素的细胞内分布

Am J Physiol. 1964 Dec;207:1237-41. doi: 10.1152/ajplegacy.1964.207.6.1237.

IDIOPATHIC DYSERYTHROPOIETIC JAUNDICE.

Blood. 1964 Jul;24:1-18.

THE LOCALIZATION OF ALBUMIN AND FIBRINOGEN IN HUMAN LIVER CELLS.白蛋白和纤维蛋白原在人肝细胞中的定位

J Cell Biol. 1964 Feb;20(2):271-9. doi: 10.1083/jcb.20.2.271.

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