造血干细胞：其异质性与调控

Haemopoietic stem cells: their heterogeneity and regulation.

作者信息

Graham G J, Wright E G

机构信息

Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.

出版信息

Int J Exp Pathol. 1997 Aug;78(4):197-218. doi: 10.1046/j.1365-2613.1997.270361.x.

DOI:10.1046/j.1365-2613.1997.270361.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2694541/

Abstract

The maintenance of the various blood cell populations in mammals is achieved by the proliferation and differentiation of precursor cells located primarily in the bone marrow. These precursor cells are all derived from a common haemopoietic stem cell population that is established during embryogenesis and functions for the lifetime of the organism. An overview is given of the various assay systems for haemopoietic stem cells, how these assays have contributed to understanding the considerable heterogeneity within the stem cell compartment, the regulation of stem cells and the development of the haemopoietic system.

摘要

哺乳动物中各种血细胞群体的维持是通过主要位于骨髓中的前体细胞的增殖和分化来实现的。这些前体细胞均源自一个共同的造血干细胞群体，该群体在胚胎发育过程中形成，并在生物体的整个生命周期中发挥作用。本文概述了造血干细胞的各种检测系统，以及这些检测如何有助于理解干细胞区室中的显著异质性、干细胞的调控以及造血系统的发育。

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