H2受体阻断后胃黏膜组胺的动员与胃液分泌
Mobilization of gastric mucosal histamine and gastric secretion after H2-receptor blockade.
作者信息
Lundell L
出版信息
Br J Pharmacol. 1973 Dec;49(4):715-7. doi: 10.1111/j.1476-5381.1973.tb08552.x.
Abstract
The effects of two H(2)-receptor antagonists (burimamide and metiamide) on the mobilization of gastric mucosal histamine, as shown by its urinary excretion and acid secretion following pentagastrin infusion, were studied in rats provided with Heidenhain pouches. Pentagastrin-induced secretion was completely inhibited without major Alterations in urinary excretion of histamine. These observations can easily be reconciled with the hypothesis that pentagastrin is not a direct stimulant of the parictal cell.
摘要
在具有海登海因小胃的大鼠中，研究了两种H₂受体拮抗剂（布立马胺和甲硫米特）对胃黏膜组胺释放的影响，通过五肽胃泌素输注后的尿排泄和胃酸分泌来显示。五肽胃泌素诱导的分泌被完全抑制，而组胺的尿排泄没有重大改变。这些观察结果很容易与五肽胃泌素不是壁细胞直接刺激物的假设相吻合。
相似文献
1
Mobilization of gastric mucosal histamine and gastric secretion after H2-receptor blockade.H2受体阻断后胃黏膜组胺的动员与胃液分泌
Br J Pharmacol. 1973 Dec;49(4):715-7. doi: 10.1111/j.1476-5381.1973.tb08552.x.
2
Effect of burimamide and metiamide on pentagastrin-stimulated gastric acid secretion and gastric mucosal blood flow in cats.布立马胺和甲硫米特对猫五肽胃泌素刺激的胃酸分泌及胃黏膜血流的影响。
Experientia. 1974 Dec 15;30(12):1435-7. doi: 10.1007/BF01919682.
3
Inhibition of in vitro stimulated gastric acid secretion by a histamine H2-receptor antagonist, metiamide.组胺H2受体拮抗剂甲硫米特对体外刺激胃酸分泌的抑制作用。
Eur J Pharmacol. 1974 Nov;29(1):83-8. doi: 10.1016/0014-2999(74)90173-3.
4
Elicidation by a H-2-receptor antagonist of the significance of mucosal histamine mobilization in exciting acid secretion.H-2受体拮抗剂引发关于黏膜组胺释放对刺激胃酸分泌的重要性的探讨。
J Physiol. 1975 Jan;244(2):365-83. doi: 10.1113/jphysiol.1975.sp010804.
5
Metiamide--an orally active histamine H2-receptor antagonist.甲硫米特——一种口服有效的组胺H2受体拮抗剂。
Agents Actions. 1973 Oct;3(3):133-7. doi: 10.1007/BF01965723.
6
Actions of metiamide, an H2-histamine receptor antagonist, on gastric H+ and pepsin secretion in dogs.H2组胺受体拮抗剂甲硫米特对犬胃H⁺和胃蛋白酶分泌的作用。
Gastroenterology. 1974 Jul;67(1):93-9.
7
Implication of gastric mucosal histamine in inhibition by isoprenaline of pentagastrin-induced gastric secretion.胃黏膜组胺在异丙肾上腺素对五肽胃泌素诱导的胃酸分泌的抑制作用中的意义。
Br J Pharmacol. 1974 Sep;52(1):69-75. doi: 10.1111/j.1476-5381.1974.tb09688.x.
8
Metiamide: an antagonist of histamine-stimulated gastric acid secretion.甲硫米特：一种组胺刺激胃酸分泌的拮抗剂。
Ann Surg. 1975 Nov;182(5):627-9. doi: 10.1097/00000658-197511000-00015.
9
The effects of burimamide on gastric acid secretion and gastric mucosal blood flow in the anaesthetized cat.布立马胺对麻醉猫胃酸分泌及胃黏膜血流的影响。
J Physiol. 1974 Mar;237(2):41P-42P.
10
The role of histamine receptors in the stimulation of gastric acid secretion.组胺受体在刺激胃酸分泌中的作用。
Am J Dig Dis. 1974 Nov;19(11):999-1006. doi: 10.1007/BF01255781.
引用本文的文献
1
Classification and biological distribution of histamine receptor sub-types. 1975.组胺受体亚型的分类及生物学分布。1975年。
Agents Actions. 1994 Dec;43(3-4):97-115; discussion 116. doi: 10.1007/BF01986677.
2
Further studies on the mode of action of isoprenaline on gastric secretion in the conscious rat.关于异丙肾上腺素对清醒大鼠胃分泌作用方式的进一步研究。
Br J Pharmacol. 1976 Sep;58(1):17-25. doi: 10.1111/j.1476-5381.1976.tb07688.x.
3
Histamine metabolism of the guinea-pig gastric mucosa.豚鼠胃黏膜的组胺代谢
J Physiol. 1976 May;257(2):419-31. doi: 10.1113/jphysiol.1976.sp011376.
4
Inhibition by metiamide of secretagogue-induced gastric acid secretion in the conscious Heidenhain pouch rat.甲硫米特对清醒海登海因小胃大鼠促分泌素诱导的胃酸分泌的抑制作用。
J Physiol. 1978 Dec;285:49-57. doi: 10.1113/jphysiol.1978.sp012556.
5
Relations between the effects of histamine, pheniramin and metiamide on spontaneous motility and the formation of cyclic AMP in the isolated rat uterus.
Naunyn Schmiedebergs Arch Pharmacol. 1975;287(3):321-7. doi: 10.1007/BF00501477.
6
Elicidation by a H-2-receptor antagonist of the significance of mucosal histamine mobilization in exciting acid secretion.H-2受体拮抗剂引发关于黏膜组胺释放对刺激胃酸分泌的重要性的探讨。
J Physiol. 1975 Jan;244(2):365-83. doi: 10.1113/jphysiol.1975.sp010804.
7
Classification and biological distribution of histamine receptor sub-types.组胺受体亚型的分类及生物学分布
Agents Actions. 1975 Oct;5(4):277-95. doi: 10.1007/BF02205232.
本文引用的文献
1
Preparation of chronic denervated gastric pouches in the rat.大鼠慢性去神经支配胃袋的制备
Am J Physiol. 1959 Aug;197:257-9. doi: 10.1152/ajplegacy.1959.197.2.257.
2
The secretory pattern of three stomach preparations in the rat.大鼠三种胃制剂的分泌模式。
J Physiol. 1970 Apr;207(2):329-50. doi: 10.1113/jphysiol.1970.sp009064.
3
Gastric secretion and its facilitation as related to gastric mucosal histamine.胃分泌及其促进作用与胃黏膜组胺的关系。
J Physiol. 1972 Oct;226(2):431-52. doi: 10.1113/jphysiol.1972.sp009992.
4
Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
Zotero 插件