血液血小板中肝素中和因子的亚细胞定位。
Subcellular localization of the heparin-neutralizing factor in blood platelets.
作者信息
Da Prada M, Jakábová M, Lüscher E F, Pletscher A, Richards J G
出版信息
J Physiol. 1976 May;257(2):495-502. doi: 10.1113/jphysiol.1976.sp011380.
Abstract
- The distribution of the heparin-neutralizing factor (platelet factor 4, PF4) in subcellular organelles of blood platelets of rabbits and man was investigated. 2. In both species the organelles storing 5-hydroxytryptamine (5-HT storage organelles) contained only trivial amounts of PF4. 3. In contrast, the content of PF4 was highest in the subcellular fractions rich in alpha-granules. 4. In conclusion, PF4 is probably localized in the alpha-granules and therefore the platelets contain at least two types of organelles (5-HT organelles and alpha-granules) capable of releasing their contents in response to the same stimuli, such as exposure to collagen, thrombin, etc.
摘要
- 对兔和人的血小板亚细胞器中肝素中和因子（血小板第4因子，PF4）的分布进行了研究。2. 在这两个物种中，储存5-羟色胺的细胞器（5-羟色胺储存细胞器）仅含有微量的PF4。3. 相比之下，富含α-颗粒的亚细胞组分中PF4的含量最高。4. 总之，PF4可能定位于α-颗粒中，因此血小板至少含有两种能够响应相同刺激（如暴露于胶原蛋白、凝血酶等）而释放其内容物的细胞器（5-羟色胺细胞器和α-颗粒）。
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