Senturk L M, Arici A
Yale University School of Medicine, Department of Obstetrics and Gynecology, New Haven, CT 06520-8063, USA.
Am J Reprod Immunol. 1998 Feb;39(2):144-51. doi: 10.1111/j.1600-0897.1998.tb00346.x.
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 family and has different biological actions in various tissue systems. Although named for its ability to inhibit proliferation of a myeloid leukemic cell line by inducing differentiation, it also regulates the growth and differentiation of embryonic stem cells, primordial germ cells, peripheral neurons, osteoblasts, adipocytes, and endothelial cells. LIF is crucial for successful implantation of the embryo in mice. Currently, there is an accumulation of data about the role of LIF in human reproduction.
This review of the literature and of our studies focuses on the expression, regulation, and effects of LIF in the human endometrium, fallopian tube, and ovarian follicle.
Human endometrium expresses LIF in a menstrual cycle-dependent manner. Maximal expression is observed between days 19 and 25 of the menstrual cycle, coinciding with the time of implantation. Various cytokines and growth factors induce endometrial LIF expression in vitro. LIF receptor is expressed in endometrial tissue throughout the menstrual cycle and on human blastocysts in a stage-dependent manner. Affecting the trophoblast differentiation pathway toward the adhesive phenotype, LIF plays a role in implantation. LIF is also expressed and secreted by the epithelial cells of the fallopian tube. Its increased expression in the tubal stromal cell cultures by the inflammatory cytokines suggests a link between salpingitis and ectopic implantation in the tube. The rising follicular fluid LIF level around the time of ovulation indicates that LIF may play a role in ovulatory events, early embryonic development, and implantation.
There is growing evidence that LIF may be one of the entities that plays a role in human reproduction.
白血病抑制因子（LIF）是白细胞介素-6家族的一种多效性细胞因子，在各种组织系统中具有不同的生物学作用。尽管它因能够通过诱导分化来抑制髓系白血病细胞系的增殖而得名，但它也调节胚胎干细胞、原始生殖细胞、外周神经元、成骨细胞、脂肪细胞和内皮细胞的生长与分化。LIF对小鼠胚胎的成功着床至关重要。目前，关于LIF在人类生殖中的作用已有大量数据积累。
本对文献及我们自身研究的综述聚焦于LIF在人子宫内膜、输卵管和卵巢卵泡中的表达、调节及作用。
人子宫内膜以月经周期依赖的方式表达LIF。在月经周期的第19至25天观察到最高表达，这与着床时间一致。多种细胞因子和生长因子在体外可诱导子宫内膜LIF表达。LIF受体在整个月经周期的子宫内膜组织中以及在人囊胚上以阶段依赖的方式表达。LIF影响滋养层细胞向黏附表型的分化途径，在着床过程中发挥作用。输卵管上皮细胞也表达并分泌LIF。炎症细胞因子使输卵管基质细胞培养物中LIF表达增加，提示输卵管炎与输卵管异位着床之间存在联系。排卵前后卵泡液中LIF水平升高表明LIF可能在排卵事件、早期胚胎发育及着床中发挥作用。
越来越多的证据表明，LIF可能是在人类生殖中发挥作用的因素之一。
