Klein M, Menneking H, Langford A, Koch K, Stahl H
Clinic for Maxillofacial Surgery, Virchow Clinic, Medical Faculty Charité, Humboldt University of Berlin, Germany.
Int J Oral Maxillofac Surg. 1998 Feb;27(1):45-8. doi: 10.1016/s0901-5027(98)80095-7.
The results are presented of afterloading high-dose-rate-radiation with iridium-192 in 34 patients with squamous cell carcinomas of the floor of the mouth and tongue. Some patients were also treated surgically or given percutaneous radio- or chemotherapy. At the time of diagnosis, 28.0% had a T2 tumour, 41.9% a T3 tumour and 30.1% a T4 tumour, 41.2% had positive lymph nodes and 2.9% distant metastases. The response rate was 64.7%, 26.5% of which were complete remissions and 38.2% partial remissions. In 61.8% of cases, the tumour was recurrent and responded with a rate as high as 57.2%, 23.9% of which were complete remissions and 33.3% partial remissions. Survival times were dependent upon therapy results. The mean survival of patients with complete remission was 40.3 months, with partial remission 16.1 months as opposed to 7.2 and 3.5 months respectively in patients showing no change or progressive disease. It can be concluded that afterloading therapy using high-dose-rate-radiation with iridium-192 achieves good palliative results and should be looked at as a supplementary treatment modality for squamous cell carcinomas of the floor of the mouth and tongue.
本文呈现了34例口底和舌鳞状细胞癌患者接受铱-192后装高剂量率放疗的结果。部分患者还接受了手术治疗或经皮放疗或化疗。诊断时，28.0%为T2期肿瘤，41.9%为T3期肿瘤，30.1%为T4期肿瘤；41.2%有阳性淋巴结，2.9%有远处转移。缓解率为64.7%，其中26.5%为完全缓解，38.2%为部分缓解。61.8%的病例肿瘤复发，缓解率高达57.2%，其中23.9%为完全缓解，33.3%为部分缓解。生存时间取决于治疗结果。完全缓解患者的平均生存期为40.3个月，部分缓解患者为16.1个月，而病情无变化或进展的患者分别为7.2个月和3.5个月。可以得出结论，使用铱-192进行后装高剂量率放疗可取得良好的姑息治疗效果，应被视为口底和舌鳞状细胞癌的一种辅助治疗方式。
