Mazeron J J, Simon J M, Le Péchoux C, Crook J M, Grimard L, Piedbois P, Le Bourgeois J P, Pierquin B
Département de Cancérologie, Hôpital Henri Mondor, Créteil, France.
Radiother Oncol. 1991 May;21(1):39-47. doi: 10.1016/0167-8140(91)90339-i.
From 1971 to 1988, 134 T1 and 145 T2 biopsy-proven squamous cell carcinomas of mobile tongue and floor of mouth were definitively managed by iridium-192. Implantations were performed using either guide gutters or afterloading plastic catheters. The prescribed dose at the reference isodose (85% of the basal dose rate, Paris system) was 60-70 Gy. Total dose was not adjusted to dose rate or tumor volume. Results of the 279 implants have been analysed to look for a possible influence of dose rate on local control and necrosis. Follow-up patients free of local recurrence is 1-180 months with average of 51 months. The 279 tumors were divided in four groups according to dose and dose rate: greater than or equal to 62.5 Gy and greater than or equal to 0.5 Gy/h (n = 130), greater than or equal to 62.5 Gy and less than 0.5 Gy/h (n = 36), less than 62.5 Gy and greater than or equal to 0.5 Gy/h (n = 81), less than 62.5 Gy and less than 0.5 Gy/h (n = 32). The four groups were comparable according to age, sex, tumor diameter and macroscopic aspect. At 5 years, the estimated local control (Kaplan Meier) was 93, 87, 79 and 52%, respectively (dose adjusted to dose rate: p less than 0.001, dose rate adjusted to dose: p less than 0.01, Log-rank); the necrosis rate was 44, 24, 37 and 5%, respectively (dose adjusted to dose rate: p = 0.08, dose rate adjusted to dose: p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
1971年至1988年期间，134例经活检证实为T1期、145例为T2期的活动期舌癌和口底鳞状细胞癌采用铱-192进行了明确治疗。植入操作使用导向槽或后装塑料导管进行。参考等剂量线（巴黎系统基础剂量率的85%）处的处方剂量为60 - 70 Gy。总剂量未根据剂量率或肿瘤体积进行调整。对这279例植入治疗的结果进行了分析，以寻找剂量率对局部控制和坏死的可能影响。随访无局部复发的患者时间为1 - 180个月，平均51个月。根据剂量和剂量率，这279个肿瘤被分为四组：大于或等于62.5 Gy且大于或等于0.5 Gy/h（n = 130），大于或等于62.5 Gy且小于0.5 Gy/h（n = 36），小于62.5 Gy且大于或等于0.5 Gy/h（n = 81），小于62.5 Gy且小于0.5 Gy/h（n = 32）。这四组在年龄、性别、肿瘤直径和宏观表现方面具有可比性。5年时，估计的局部控制率（Kaplan - Meier法）分别为93%、87%、79%和52%（剂量根据剂量率调整：p < 0.00I，剂量率根据剂量调整：p < 0.01，对数秩检验）；坏死率分别为44%、24%、37%和5%（剂量根据剂量率调整：p = 0.08，剂量率根据剂量调整：p < 0.01）。（摘要截短为250字）
