肿瘤坏死因子受体相关因子4（TRAF4）在小鼠发育过程中的表达模式。
Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.
作者信息
Masson R, Régnier C H, Chenard M P, Wendling C, Mattei M G, Tomasetto C, Rio M C
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Strasbourg, France.
出版信息
Mech Dev. 1998 Feb;71(1-2):187-91. doi: 10.1016/s0925-4773(97)00192-5.
This is the first in situ hybridization analysis of expression of a tumor necrosis factor (TNF) receptor associated factor (TRAF) during development. TRAF4 is observed throughout mouse embryogenesis, most notably during ontogenesis of the central (CNS) and peripheral (PNS) nervous system, and of nervous tissues of sensory organs. TRAF4 is preferentially expressed by post-mitotic undifferentiated neurons. Interestingly, TRAF4 remains expressed in the adult hippocampus and olfactory bulb, known to contain multipotential cells responsible for neoneurogenesis.
这是首次对肿瘤坏死因子（TNF）受体相关因子（TRAF）在发育过程中的表达进行原位杂交分析。在整个小鼠胚胎发育过程中均观察到TRAF4，最显著的是在中枢神经系统（CNS）和外周神经系统（PNS）以及感觉器官的神经组织的个体发生过程中。TRAF4优先由有丝分裂后未分化的神经元表达。有趣的是，TRAF4在成体海马体和嗅球中仍然表达，已知这些部位含有负责神经新生的多能细胞。
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