Fujiwara Y, Kaji T
Department of Environmental Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Res Commun Mol Pathol Pharmacol. 1997 Jul;97(1):95-106.
We investigated the effect of zinc sulfate on the proliferation of cultured bovine aortic smooth muscle cells stimulated with or without growth factors. Zinc had no effect on the incorporation of [3H]thymidine into the acid-insoluble fraction of the cells stimulated with or without platelet-derived growth factor or transforming growth factor beta 1. However, it was shown that stimulation of the [3H]thymidine incorporation by either basic or acidic fibroblast growth factor was significantly potentiated by zinc. Other cations including copper, manganese and nickel did not exhibit such an activity. The present data suggest that zinc is a particular heavy metal which potentiates vascular smooth muscle cell proliferation stimulated by basic and acidic fibroblast growth factors as well as thrombospondin. Zinc may be involved in the intimal hyperplasia of atherosclerosis.
我们研究了硫酸锌对有无生长因子刺激的培养牛主动脉平滑肌细胞增殖的影响。锌对有无血小板衍生生长因子或转化生长因子β1刺激的细胞中[3H]胸苷掺入酸不溶性部分均无影响。然而，结果表明，锌可显著增强碱性或酸性成纤维细胞生长因子对[3H]胸苷掺入的刺激作用。包括铜、锰和镍在内的其他阳离子未表现出这种活性。目前的数据表明，锌是一种特殊的重金属，可增强碱性和酸性成纤维细胞生长因子以及血小板反应蛋白刺激的血管平滑肌细胞增殖。锌可能参与动脉粥样硬化的内膜增生。
