Pell J P, Lee A J
Department of Public Health, Greater Glasgow Health Board.
Scott Med J. 1997 Apr;42(2):47-8. doi: 10.1177/003693309704200207.
Claudicants usually die from concomitant conditions. Therefore, surgical interventions are aimed at improving quality of life, rather than survival. This study compared the impact of percutaneous transluminal angioplasty (PTA), arterial reconstruction and conservative management on quality of life. SF36 questionnaires were completed by 201 newly referred claudicants prior to treatment and six months later. Multiple regression was used to compare the quality of life scores following the three treatments after adjustment for baseline scores, age, sex, site of disease and disease severity. Follow-up data were available on 81% of the 195 patients alive. Nineteen (10%) of these had undergone PTA and 19 (10%) reconstruction. All aspects of quality of life deteriorated following conservative treatment. PTA and arterial reconstruction produced significant improvements in both pain and physical functioning after adjustment for case-mix. Although unlikely to improve survival, PTA and arterial reconstruction are associated with significant improvements in quality of life.
间歇性跛行患者通常死于合并症。因此，手术干预旨在提高生活质量，而非延长生存期。本研究比较了经皮腔内血管成形术（PTA）、动脉重建术和保守治疗对生活质量的影响。201名新转诊的间歇性跛行患者在治疗前及治疗六个月后完成了SF36问卷调查。采用多元回归分析比较三种治疗方法在调整基线评分、年龄、性别、疾病部位和疾病严重程度后的生活质量得分。195名存活患者中有81%提供了随访数据。其中19名（10%）接受了PTA治疗，19名（10%）接受了重建手术。保守治疗后生活质量的各个方面均有所下降。在调整病例组合后，PTA和动脉重建术在疼痛和身体功能方面均有显著改善。虽然PTA和动脉重建术不太可能提高生存率，但它们与生活质量的显著改善相关。
