Shpigel N Y, Winkler M, Ziv G, Saran A
The Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Vet Rec. 1998 Feb 7;142(6):135-7. doi: 10.1136/vr.142.6.135.
The relationship between in vitro sensitivity to antimicrobials and the outcome of treatment was studied in 228 cows with coliform mastitis. All the cows were treated with a preparation containing sulphonamide and trimethoprim, and 197 of them were also treated with a non-steroidal anti-inflammatory drug (NSAID). The relationship between in vitro sensitivity to sulphonamide/trimethoprim and recovery was analysed by multivariate logistic regression. The possible confounding effects of treatment with an NSAID, days in lactation, parity, herd, and type of infecting organism were tested. Only treatment with an NSAID had a significant confounding effect and was included in the final statistical model. The recovery rate of the 165 cows infected by coliforms that were sensitive to sulphonamide/trimethoprim (89.1 per cent) was higher than that of the 63 cows infected by coliforms that were resistant to sulphonamide/trimethoprim (74.6 per cent). The odds ratio of recovery for the cases associated with organisms that were sensitive to sulphonamide/trimethoprim relative to the cases associated with organisms that were resistant to sulphonamide/trimethoprim was 2.75, with a 95 per cent confidence from 1.25 to 5.85. The odds ratio of recovery for the cases treated with an NSAID relative to the cases treated with sulphonamide/trimethoprim only was 2.76 with a 95 per cent confidence interval from 1.12 to 6.79.
对228头患有大肠埃希菌性乳腺炎的奶牛，研究了其体外抗菌敏感性与治疗结果之间的关系。所有奶牛均接受了含有磺胺和甲氧苄啶的制剂治疗，其中197头还接受了非甾体抗炎药（NSAID）治疗。通过多因素逻辑回归分析了对磺胺/甲氧苄啶的体外敏感性与康复之间的关系。测试了使用NSAID治疗、泌乳天数、胎次、牛群和感染微生物类型可能产生的混杂效应。只有使用NSAID治疗具有显著的混杂效应，并被纳入最终的统计模型。对磺胺/甲氧苄啶敏感的大肠埃希菌感染的165头奶牛的康复率（89.1%）高于对磺胺/甲氧苄啶耐药的大肠埃希菌感染的63头奶牛的康复率（74.6%）。与对磺胺/甲氧苄啶耐药的微生物相关病例相比，与对磺胺/甲氧苄啶敏感的微生物相关病例的康复优势比为2.75，95%置信区间为1.25至5.85。与仅接受磺胺/甲氧苄啶治疗的病例相比，接受NSAID治疗的病例的康复优势比为2.76，95%置信区间为1.12至6.79。
