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一些4-取代亚苄基氨基-5-[3(5)-甲基-5(3)-苯基-1H-1-吡唑基]-2,4-二氢-3H-1,2,4-三唑-3-硫酮衍生物的合成、结构解析及其抗菌活性

Synthesis and structure elucidation of some 4-substituted benzylidene amino-5-[3(5)-methyl-5(3)-phenyl-1H-1-pyrazolyl]-2,4-dihydro-3H-1,2,4- triazole-3-thione derivatives with their antimicrobial activities.

作者信息

Doğan H N, Büyüktimkin S, Rollas S, Yemni E, Cevikbaş A

机构信息

University of Marmara, Faculty of Pharmacy, Pharmaceutical Chemistry Department, Haydarpasa, Istanbul, Turkey.

出版信息

Farmaco. 1997 Aug-Sep;52(8-9):565-8.

PMID:9507666
Abstract

A new series of 4-substituted benzylideneamino-5[3(5)-methyl-5(3)-phenyl-1H-1-pyrazolyl]-2 ,4-dihydro-3H- 1,2,4-triazole-3-thione was synthesized by reaction of I with suitable aldehyde and tested for their antimicrobial activities against six microorganisms. Most of the compounds showed antibacterial activity against Gram positive bacteria.

摘要

通过I与合适的醛反应合成了一系列新的4-取代亚苄基氨基-5[3(5)-甲基-5(3)-苯基-1H-1-吡唑基]-2,4-二氢-3H-1,2,4-三唑-3-硫酮,并测试了它们对六种微生物的抗菌活性。大多数化合物对革兰氏阳性菌表现出抗菌活性。

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