Synthesis and biological action of 3-R-4-substituted-delta2-1,2,4-triazoline-5-thione.

In the reaction of hydroiodide of methyl ester of 3-thiocarbazic acid with diethylamine and morpholine hydroiodide of 2-amino-1-substituted-guanidine [I-II] were obtained. These compounds were then converted to respective 3-R-4-substituted-delta2-1,2,4-triazoline-5-thione [III-X] in the reaction with isothiocyanates. Some of these compounds were screened for their antibacterial activities.