螯合剂作为潜在的抗肿瘤药物：α-(N)-杂环腙和双-α-(N)-杂环腙
Chelating agents as potential antitumorals: alpha-(N)-heterocyclic hydrazones and bis-alpha-(N)-heterocyclic hydrazones.
作者信息
Savini L, Massarelli P, Chiasserini L, Nencini C, Pellerano C
机构信息
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy.
出版信息
Farmaco. 1997 Oct;52(10):609-13.
PMID:9507672
Abstract
A number of pyruvic acid and methylpyruvate alpha-(N)-heterocyclic hydrazones has been synthesized. Bis-heterocyclic hydrazones were obtained from reaction with pyruvic carboxaldehyde. Some complexes of Ni(II) were prepared and characterized as neutral complexes. All these compounds have been evaluated for cytotoxicity against P388 and HL-60 leukemia.
摘要
已合成了多种丙酮酸和甲基丙酮酸α-(N)-杂环腙。通过与丙酮酸羧醛反应得到了双杂环腙。制备了一些镍(II)配合物，并将其表征为中性配合物。对所有这些化合物针对P388和HL-60白血病的细胞毒性进行了评估。
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