1,2,4-三嗪-3-腙的一些新型硫醚的合成及其抗癌和抗人类免疫病毒活性测定
Synthesis of some new thioethers of 1,2,4-triazine-3-hydrazones and assays for their anticancer and anti human immune virus activities.
作者信息
Abdel-Rahman R M, Seada M, Fawzy M, el-Baz I
机构信息
Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt.
出版信息
Farmaco. 1993 Mar;48(3):397-406.
PMID:8323671
Abstract
A number of various thioethers derived from 3-hydrazone-5,6-diphenyl-1,2,4-triazines have been synthesized and evaluated for anticancer and anti HIV activities. The structures are supported by elemental analysis, IR, UV and 1H-NMR spectral data. Most of the tested compounds displayed a significant activity against Leukemia/Lymphoma, CNS, Ovarian and Small cell lung cancer.
摘要
已经合成了多种源自3-腙基-5,6-二苯基-1,2,4-三嗪的硫醚，并对其抗癌和抗HIV活性进行了评估。其结构由元素分析、红外光谱、紫外光谱和1H-核磁共振光谱数据证实。大多数受试化合物对白血病/淋巴瘤、中枢神经系统、卵巢癌和小细胞肺癌显示出显著活性。
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