Uzunoğlu S, Tosun A U, Ozden T, Yeşilada E, Berkem R
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Hipodrom, Ankara, Turkey.
Farmaco. 1997 Oct;52(10):619-23.
Nine 1,2,5-trisubstituted benzimidazole derivatives were prepared and their structure have been elucidated by IR, NMR spectral data and elemental analyses. Analgesic activity of the compounds prepared was investigated in mice by modified KOSTER test. Anti-inflammatory activity of these compounds was investigated by a carregeenan-induced hind paw edema model in mice. Their antibacterial activities were examined against S. aureus, E. faecalis, E. coli, P. aeruginosa, and antifungal activity against three kinds of yeast-like fungi (C. albicans, C. parapsilosis, C. stellatoidea).
制备了九种1,2,5-三取代苯并咪唑衍生物，并通过红外光谱、核磁共振光谱数据和元素分析对其结构进行了阐明。通过改良的科斯特试验在小鼠中研究了所制备化合物的镇痛活性。通过角叉菜胶诱导的小鼠后爪水肿模型研究了这些化合物的抗炎活性。检测了它们对金黄色葡萄球菌、粪肠球菌、大肠杆菌、铜绿假单胞菌的抗菌活性，以及对三种酵母样真菌（白色念珠菌、近平滑念珠菌、星状念珠菌）的抗真菌活性。
