Synthesis and evaluation of 1,5-benzodiazepines with bridged cycloalkyl substituents at the N-1 position as potent and selective CCK-B Ligands.
作者信息
Finizia G, Donati D, Pentassuglia G, Polinelli S, Tarzia G, Tranquillini M E, Ursini A
机构信息
Glaxo Wellcome S.p.A., Medicines Research Center, Verona, Italy.
出版信息
Arch Pharm (Weinheim). 1998 Jan;331(1):41-4. doi: 10.1002/(sici)1521-4184(199801)331:1<41::aid-ardp41>3.0.co;2-s.
Abstract
The synthesis and biological evaluation of 3-ureido and 3-carbamate derivatives of 1,5-benzodiazepines bearing bridged cycloalkyl substituents at N-1 are reported. Their activity as CCK-B receptor ligands is briefly discussed.
摘要
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