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Diastereomeric separation of 1,5-benzodiazepines due to the presence of a chiral centre on the N-5 alkylic chain.

作者信息

Araldi G L, Donati D, Tranquillini M E, Ursini A

机构信息

Glaxo Wellcome S.p.A., Medicines Research Centre, Verona, Italy.

出版信息

Farmaco. 1998 Jan;53(1):49-54. doi: 10.1016/s0014-827x(97)00004-9.

DOI:10.1016/s0014-827x(97)00004-9
PMID:9543726
Abstract

The presence of a chain bearing a stereogenic centre at the N-5 position of 1-(1-adamantylmethyl)-3-arylureido-2,4-dioxo-1,5-benzodiazep ines induces optical resolution. The synthesis of these compounds and their potency as potential CCK-B receptor antagonists is discussed briefly here.

摘要

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