Carranza-Lira S, Tserotas K, Morán C, Merino G, Barahona E, Bermúdez J A
Gynecologic Endocrinology and Andrology Section, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México D.F.
Arch Androl. 1998 Mar-Apr;40(2):159-62. doi: 10.3109/01485019808987939.
Thirteen patients with asthenozoospermia and semen analysis suggestive of infection were studied and divided at random into 2 groups according to the antibiotic treatment they received: (I) ciprofloxacine 250 mg every 12 hours by 14 days per os (n = 7) and (II) trimethoprim 160 mg and sulfamethoxazole 800 mg every 12 hours by 14 days per os (n = 6). Their couples received the same treatment. Changes in sperm density, morphology, viability, motility, agglutination, pH, and presence of leukocytes were analyzed before and after treatment. The average of morphologically normal sperms significantly decreased after treatment in the ciprofloxacine group; sperm with grade III motility increased in the trimethoprim-sulfamethoxazole group, but without statistical significance. With these preliminary results, it can be concluded that antibiotic administration modifies some of the spermatic parameters, particularly motility and morphology, in patients whose semen analysis parameters suggested infection.
对13例弱精子症且精液分析提示有感染的患者进行了研究，并根据他们接受的抗生素治疗随机分为2组：（I）口服环丙沙星250mg，每12小时1次，共14天（n = 7）；（II）口服甲氧苄啶160mg和磺胺甲恶唑800mg，每12小时1次，共14天（n = 6）。他们的配偶接受相同的治疗。分析治疗前后精子密度、形态、活力、运动能力、凝集、pH值和白细胞存在情况的变化。环丙沙星组治疗后形态正常精子的平均值显著下降；甲氧苄啶 - 磺胺甲恶唑组III级运动能力的精子有所增加，但无统计学意义。根据这些初步结果，可以得出结论，对于精液分析参数提示有感染的患者，使用抗生素会改变一些精子参数，特别是运动能力和形态。
