De Almeida M, Jouannet P
Clin Exp Immunol. 1981 Jun;44(3):567-75.
A group of 14 infertile men with significant titres of anti-sperm antibodies in their sera and seminal plasma were treated with dexamethasone acetate at 2 of 3 mg/day for s13 or 9 weeks respectively. Response to the treatment was evaluated by the evolution of seminal and circulating anti-sperm antibodies and semen characteristics. An overall decline in the anti-sperm antibodies was observed. Serum spermotoxicity and seminal agglutinins decreased below detectable levels in 67 and 58% of the men respectively. The decrease in both kinds of antibodies was closely correlated. Serum sperm agglutination titres fell slightly (2 to 3 log2 dilutions) in most cases. The disappearance of antibodies from the semen was accompanied by decreased autoagglutination and increased percentages of progressively motile spermatozoa. In two oligozoospermic men a striking increase in the sperm count was observed. Pregnancies occurred in three couples at times when serum spermotoxic and seminal agglutinating antibodies were undetectable and semen characteristics were normal.
对14名血清和精浆中抗精子抗体效价显著的不育男性进行了醋酸地塞米松治疗，剂量分别为每日2或3毫克，疗程分别为13周或9周。通过精液和循环抗精子抗体的变化以及精液特征来评估治疗反应。观察到抗精子抗体总体下降。血清精子毒性和精液凝集素分别在67%和58%的男性中降至检测水平以下。两种抗体的下降密切相关。大多数情况下，血清精子凝集效价略有下降（2至3个log2稀释度）。精液中抗体的消失伴随着自身凝集减少和进行性运动精子百分比增加。在两名少精子症男性中观察到精子计数显著增加。在三对夫妇中，当血清精子毒性和精液凝集抗体检测不到且精液特征正常时，发生了妊娠。
