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[抗疟药物可及性对疟疾发病率和氯喹耐药性的影响。在图巴(塞内加尔)开展的一项研究]

[Impact of antimalarial drug accessibility on malarial morbidity and chloroquine resistance. A study carried out in Touba (Senegal)].

作者信息

Faye O, Fall M, Gaye O, Bah I B, Dieng T, Dieng Y, Ndir O, Diallo S

机构信息

Départment de parasitologie, Faculté de médecine, Université Cheikh Anta Diop, Dakar.

出版信息

Bull Soc Pathol Exot. 1997;90(5):318-20.

PMID:9507760
Abstract

In Touba, more important accessibility to antimalarial drugs and their uncontrolled use let to assure that the rate of malarial morbidity would be lower there than in other place in Senegal whereas the rate of chloroquine resistance would be higher. A checking survey of these assumptions has been carried out from october 15 to november 10, 1995 in Touba's health center. Among 227 feverish subjects investigated, 111 were Plasmodium falciparum carriers. Malarial bouts accounted for 48.9% of the feverish fits observed and for the major cause of consultation during the rainy season. These figures are higher than those usually observed in urban environment. Conversely, the rate of chloroquine resistance is lower than those observed in urban zones, since the therapeutic efficacy of chloroquine on Plasmodium falciparum was 100% in that survey.

摘要

在图巴,抗疟药物更容易获得且使用不受控制,这使得人们认为那里的疟疾发病率会低于塞内加尔的其他地方,而氯喹耐药率会更高。1995年10月15日至11月10日,在图巴的健康中心对这些假设进行了一次核查调查。在接受调查的227名发热患者中,111人是恶性疟原虫携带者。疟疾发作占观察到的发热发作的48.9%,是雨季就诊的主要原因。这些数字高于通常在城市环境中观察到的数字。相反,氯喹耐药率低于城市地区观察到的耐药率,因为在那次调查中氯喹对恶性疟原虫的治疗效果为100%。

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