Becker A J, Stief C G, Machtens S, Schultheiss D, Hartmann U, Truss M C, Jonas U
Department of Urology, Medizinsche Hochschule Hannover, Germany.
J Urol. 1998 Apr;159(4):1214-6.
For most patients with erectile dysfunction oral agents are a preferred treatment option. Oral or buccal phentolamine has been shown to produce full erections in impotent subsets of study populations. We evaluate the efficacy of oral phentolamine.
After a comprehensive evaluation 44 patients with recent onset (less than 3 years) of erectile dysfunction and a high likelihood of organogenic etiology underwent a prospective, double-blind and placebo controlled trial with oral phentolamine after placebo.
After placebo 4 of the 44 patients who reported full erections were excluded from study. Of the 40 patients in the double-blind phase full erections were achieved by 2 of 10 with placebo, and 3 of 10 with 20 mg., 5 of 10 with 40 mg. and 4 of 10 with 60 mg. phentolamine. There were no serious complications observed during the study, and only a single minor side effect occurred in 1 patient after 60 mg. phentolamine.
Our results indicate that oral phentolamine may be of benefit for the treatment of erectile dysfunction. Further studies are required to corroborate our findings.
对于大多数勃起功能障碍患者而言，口服药物是首选的治疗选择。口服或颊部应用酚妥拉明已被证明能使研究人群中的阳痿亚组实现完全勃起。我们评估口服酚妥拉明的疗效。
在进行全面评估后，44例近期发病（少于3年）且极有可能由器质性病因导致勃起功能障碍的患者，在服用安慰剂后接受了口服酚妥拉明的前瞻性、双盲及安慰剂对照试验。
服用安慰剂后，44例报告有完全勃起的患者中有4例被排除在研究之外。在双盲阶段的40例患者中，服用安慰剂的10例中有2例实现了完全勃起，服用20毫克酚妥拉明的10例中有3例，服用40毫克的10例中有5例，服用60毫克的10例中有4例。研究期间未观察到严重并发症，仅1例患者在服用60毫克酚妥拉明后出现1次轻微副作用。
我们的结果表明，口服酚妥拉明可能对治疗勃起功能障碍有益。需要进一步研究来证实我们的发现。
