Han T S, Feskens E J, Lean M E, Seidell J C
Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, UK.
Diabet Med. 1998 Feb;15(2):129-35. doi: 10.1002/(SICI)1096-9136(199802)15:2<129::AID-DIA535>3.0.CO;2-2.
The aims of this study were to establish the associations of stature, body mass index, waist to hip ratio, and waist circumference with Type 2 (non-insulin-dependent) diabetes mellitus in a random sample of 5887 men and 7018 women aged 20-59 years in a cross-sectional study set in The Netherlands. The crude prevalence of Type 2 diabetes (overall 1.58% in men, 0.94% in women) was significantly (p < 0.01) higher in shorter subjects and those with high body mass index, high waist to hip ratio, and larger waist circumference. Odds ratios and 95% confidence intervals (95% CI) were adjusted for age, cigarette smoking, alcohol consumption, physical activity, and education. Compared to the tallest tertile of height, odds ratios for Type 2 diabetes were 4.4 (95% CI: 1.3 to 11.5) in men and 1.6 (95% CI: 0.8 to 3.2) in women whose height was in the shortest tertile. Compared to the lowest tertile, odds ratios for Type 2 diabetes were 18.4 (95% CI: 4.3 to 78.5) in men and 5.3 (95% CI: 2.0 to 14.0) in women with waist to hip ratio in the highest tertile, 4.1 (95% CI: 2.0 to 8.4) in men and 2.1 (95% CI: 1.0 to 4.2) in women with body mass index in the highest tertile, and 4.9 (95% CI: 2.1 to 11.7) in men and 2.7 (95% CI: 1.2 to 5.9) in women with waist circumference in the highest tertile. In conclusion, although in longitudinal studies waist is a powerful predictor of diabetes incidence, Type 2 diabetes in a cross-sectional survey is associated with shortness in stature, as well as large waist circumference and high body mass index, and particularly strongly with high waist to hip ratio, suggesting that the development of Type 2 diabetes may modify hip circumference independently of body fat.
在荷兰开展的一项横断面研究中，对年龄在20至59岁之间的5887名男性和7018名女性随机样本进行研究，旨在确定身高、体重指数、腰臀比和腰围与2型（非胰岛素依赖型）糖尿病之间的关联。在身材较矮以及体重指数高、腰臀比高和腰围较大的受试者中，2型糖尿病的粗患病率（男性总体为1.58%，女性为0.94%）显著更高（p<0.01）。对年龄、吸烟、饮酒、身体活动和教育程度进行了比值比和95%置信区间（95%CI）的调整。与身高最高三分位数的男性相比，身高处于最矮三分位数的男性患2型糖尿病的比值比为4.4（95%CI：1.3至11.5），女性为1.6（95%CI：0.8至3.2）。与最低三分位数相比，腰臀比处于最高三分位数的男性患2型糖尿病的比值比为18.4（95%CI：4.3至78.5），女性为5.3（95%CI：2.0至14.0）；体重指数处于最高三分位数的男性为4.1（95%CI：2.0至8.4），女性为2.1（95%CI：1.0至4.2）；腰围处于最高三分位数的男性为4.9（95%CI：2.1至11.7），女性为2.7（95%CI：1.2至5.9）。总之，虽然在纵向研究中腰围是糖尿病发病率的有力预测指标，但在横断面调查中，2型糖尿病与身材矮小、腰围大、体重指数高有关，尤其与高腰臀比密切相关，这表明2型糖尿病的发生可能独立于体脂改变臀围。
