Al-Hakami Reham G, Mashraqi Alaa Y, Shannaq Rola Ali Atiah, Kaabi Yahia A
Reham Ghazi Al-hakami, BSc. Department of Medical Laboratory Technology, College of Applied Medical Sciences, Medical Research Center, Jazan University, Jazan, Saudi Arabia.
Alaa Yahia Mashraqi, BSc. Department of Medical Laboratory Technology, College of Applied Medical Sciences, Medical Research Center, Jazan University, Jazan, Saudi Arabia.
Pak J Med Sci. 2024 Jan-Feb;40(3Part-II):308-312. doi: 10.12669/pjms.40.3.7686.
This study investigated the association of the GHRd3 polymorphism with height and type-2 diabetes mellitus (T2DM) in Saudi Arabia.
This case-control study included a total of 284 participants, divided into healthy controls (n = 142) and patients with T2DM (n = 142), recruited from Jazan University Hospital, southwest of Saudi Arabia in the period between January to September 2022. The GHRd3 polymorphism was genotyped using multiplex PCR. The correlation between height and genotypes was analyzed using one-way analysis of variance. The association between GHRd3 polymorphism and T2DM was assessed using logistic regression analysis.
The data showed a significant difference between the means of heights associated with each GHRd3 genotype, flfl, fld3, and d3d3. Logistic regression analysis showed no association between GHRd3 variants and T2DM.
Homozygous GHRd3 polymorphism carriers, d3d3 genotype, were taller than fld3 or flfl carriers in our population. None of the GHRd3 variants were associated with T2DM. Thus, the GHRd3 polymorphism has growth-related actions with a minor contribution to T2DM. However, more studies with a larger sample size are required to confirm these findings.
本研究调查了沙特阿拉伯人群中生长激素受体缺失3（GHRd3）基因多态性与身高及2型糖尿病（T2DM）之间的关联。
本病例对照研究共纳入284名参与者，分为健康对照组（n = 142）和T2DM患者组（n = 142），于2022年1月至9月期间从沙特阿拉伯西南部的吉赞大学医院招募。采用多重聚合酶链反应（PCR）对GHRd3基因多态性进行基因分型。使用单因素方差分析分析身高与基因型之间的相关性。采用逻辑回归分析评估GHRd3基因多态性与T2DM之间的关联。
数据显示，与每种GHRd3基因型（flfl、fld3和d3d3）相关的身高均值之间存在显著差异。逻辑回归分析显示，GHRd3基因变异与T2DM之间无关联。
在我们的研究人群中，GHRd3基因多态性纯合子携带者（d3d3基因型）比fld3或flfl携带者更高。GHRd3基因变异均与T2DM无关。因此，GHRd3基因多态性具有与生长相关的作用，对T2DM的影响较小。然而，需要更多样本量更大的研究来证实这些发现。
