肾上腺切除诱导颗粒细胞丢失后大鼠齿状回中细胞周期调节蛋白细胞周期蛋白D1的表达改变。
Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss.
作者信息
Postigo J A, Van der Werf Y D, Korf J, Krugers H J
机构信息
Department of Biological Psychiatry, Graduate School for Behavioral, and Cognitive Neurosciences, University of Groningen, The Netherlands.
出版信息
Neurosci Lett. 1998 Jan 30;241(2-3):107-10. doi: 10.1016/s0304-3940(97)00981-6.
The loss of dentate gyrus (DG) granular cells after removal of the rat adrenal glands (ADX) is mediated by a process that is apoptotic in nature. The present study was initiated to compare changes in the immunocytochemical distribution of the cell-cycle regulatory protein cyclin D1, which has been implicated in apoptosis, with the loss of DG granular cells after ADX. Our data indicate that cyclin D1-immunoreactivity (cyclin D1-ir) is enhanced in the rat dentate gyrus after adrenalectomy. The enhanced cyclin D1-ir shows a close relationship, both in time and space, with granular cell loss in the rat dentate gyrus that occurs after adrenalectomy. However, the enhanced cyclin D1-immunoreactivity was present in microglia and radial glia rather than in the dentate gyrus granular cells. This suggests that cyclin D1 is not directly involved in apoptosis of granular cells in the rat dentate gyrus after adrenalectomy.
大鼠肾上腺切除术后齿状回（DG）颗粒细胞的丢失是由一个本质上为凋亡的过程介导的。本研究旨在比较细胞周期调节蛋白细胞周期蛋白D1的免疫细胞化学分布变化（该蛋白与凋亡有关）与肾上腺切除术后DG颗粒细胞的丢失情况。我们的数据表明，肾上腺切除术后大鼠齿状回中细胞周期蛋白D1免疫反应性（cyclin D1-ir）增强。增强的cyclin D1-ir在时间和空间上均与肾上腺切除术后大鼠齿状回中的颗粒细胞丢失密切相关。然而，增强的细胞周期蛋白D1免疫反应性存在于小胶质细胞和放射状胶质细胞中，而非齿状回颗粒细胞中。这表明细胞周期蛋白D1在肾上腺切除术后大鼠齿状回颗粒细胞的凋亡中不直接起作用。
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