Van Landeghem G F, Sikström C, Beckman L E, Adolfsson R, Beckman L
Department of Medical Genetics, Umeå University, Sweden.
Neuroreport. 1998 Jan 26;9(2):177-9. doi: 10.1097/00001756-199801260-00001.
Significant associations between the transferrin (TF) variant C2 and a number of disorders suspected to be caused by oxygen free radicals have been reported. Thus an increased frequency of the TFC2 variant has been found in patients with Alzheimer's disease (AD), and it has been hypothesized that AD is caused by free radical damage due to defective binding of iron and aluminium by TFC2. In a study of 64 patients with AD from northern Sweden we were able to confirm the association between TFC2 and AD, but there were no significant differences between TFC2 and other TF variants with respect to the binding of iron and aluminium.
据报道，转铁蛋白（TF）变体C2与一些疑似由氧自由基引起的疾病之间存在显著关联。因此，在阿尔茨海默病（AD）患者中发现TFC2变体的频率增加，并且有人推测AD是由TFC2对铁和铝的结合缺陷导致的自由基损伤所引起的。在一项对瑞典北部64名AD患者的研究中，我们能够证实TFC2与AD之间的关联，但在铁和铝的结合方面，TFC2与其他TF变体之间没有显著差异。
