Overstreet D H, Pucilowski O, Retton M C, Delagrange P, Guardiola-Lemaitre B
Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill 27599-7178, USA.
Neuroreport. 1998 Jan 26;9(2):249-53. doi: 10.1097/00001756-199801260-00014.
The Flinders Sensitive Line (FSL) rats have been proposed as a genetic animal model of depression because their innately high immobility in the forced swim test is counteracted by antidepressants. This model was used to test the acute and chronic effects of two novel compounds which have either an agonist or antagonist-like effect at melatonin receptors. In the acute study FSL and control Flinders Resistant Line (FRL) rats were unaffected by either the agonist S 20304 (1 or 20 mg/kg) or the antagonist S 20928 (1 or 10 mg/kg) given 1 h prior to a single 5 min swim test. In the chronic study a reduction in immobility in the FSL rats at the highest dose of the agonist was the only significant drug effect. These findings suggest that the melatonin receptor agonist S 20304 may have antidepressant potential.
弗林德斯敏感品系（FSL）大鼠被认为是抑郁症的遗传动物模型，因为它们在强迫游泳试验中天生具有较高的不动性，而抗抑郁药可抵消这种特性。该模型用于测试两种新型化合物的急性和慢性作用，这两种化合物对褪黑素受体具有激动剂或拮抗剂样作用。在急性研究中，FSL大鼠和对照弗林德斯抗性品系（FRL）大鼠在单次5分钟游泳试验前1小时给予激动剂S 20304（1或20mg/kg）或拮抗剂S 20928（1或10mg/kg）后均未受到影响。在慢性研究中，激动剂最高剂量组的FSL大鼠不动性降低是唯一显著的药物效应。这些发现表明，褪黑素受体激动剂S 20304可能具有抗抑郁潜力。
