Canlon B, Fransson A
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Neuroreport. 1998 Jan 26;9(2):269-74. doi: 10.1097/00001756-199801260-00017.
Sound conditioning guinea pigs to a 6.3 kHz tone at 78 dB SPL for either 13 or 24 days provides significant physiological (auditory brain stem responses, ABR; and distortion product otoacoustic emissions, DPOAE) and morphological (cochleograms) protection against a subsequent traumatic exposure (6.3 kHz, 100 dB SPL for 24 h) delivered 2 h after sound conditioning. Threshold shifts (ABR, DPOAE) were significantly reduced and the degree of hair cell loss was minimal. When a 1 week pause was given between the end of the sound conditioning and the traumatic exposure, protection was still observed, but to a lesser degree. These findings demonstrate that mid-frequency sound conditioning protects against noise trauma and that the protective effect is maintained for at least 1 week.
将豚鼠置于78分贝声压级的6.3千赫纯音环境中进行13天或24天的声音预处理，可对随后在声音预处理2小时后施加的创伤性暴露（6.3千赫，100分贝声压级，持续24小时）提供显著的生理（听觉脑干反应，ABR；畸变产物耳声发射，DPOAE）和形态学（耳蜗图）保护。阈值变化（ABR、DPOAE）显著降低，毛细胞损失程度最小。当在声音预处理结束和创伤性暴露之间给予1周的间隔时，仍可观察到保护作用，但程度较小。这些发现表明，中频声音预处理可预防噪声性创伤，且保护作用至少可维持1周。
