Donadio J V, Holley K E, Ferguson R H, Ilstrup D M
Mayo Clin Proc. 1976 Aug;51(8):484-94.
We report a prospective randomized study of 39 patients with systemic lupus erythematosus and progressive glomerulonephritis who were assigned to treatment groups that received either prednisone alone or prednisone and cyclophosphamide combined. They received treatment for 6 months and were then followed up for an additional 18 months. No difference in outcome was seen in the two groups at the end of 6 months. Among patients followed up for an average of 24 months, fewer individuals showed later renal progression among those treated with cyclophosphamide and prednisone than among the group treated with prednisone alone.
我们报告了一项针对39例系统性红斑狼疮合并进行性肾小球肾炎患者的前瞻性随机研究，这些患者被分配到接受单独泼尼松治疗或泼尼松与环磷酰胺联合治疗的治疗组。他们接受了6个月的治疗，随后又随访了18个月。6个月末，两组的结果没有差异。在平均随访24个月的患者中，与单独接受泼尼松治疗的组相比，接受环磷酰胺和泼尼松治疗的患者中出现后期肾脏进展的个体较少。
