Paquet P, Hustinx R, Rigo P, Piérard G E
Department of Dermatopathology, University of Liège, CHU Sart-Tilman, Belgium.
Melanoma Res. 1998 Feb;8(1):59-62. doi: 10.1097/00008390-199802000-00010.
The correct staging of potentially metastatic melanoma is essential for an appropriate therapeutic attitude. Current methods include computed tomography, magnetic resonance imaging, ultrasonography and scintigraphy. Another tool is whole-body positron tomography using the radiopharmaceutical 2-fluorine-18-fluoro-2-deoxy-D-glucose as an emitter because it accumulates inside neoplasms, especially melanoma. We report two cases of malignant melanoma in which computed tomography and magnetic resonance imaging suggested visceral metastatic spread. In contrast, whole-body positron emission tomography indicated the absence of metastases, and this was confirmed by histological examination of the organs where metastases were suspected. Whole-body positron emission tomography appears to have high specificity and sensitivity for clinical melanoma staging.
对潜在转移性黑色素瘤进行正确分期对于采取恰当的治疗态度至关重要。目前的方法包括计算机断层扫描、磁共振成像、超声检查和闪烁扫描法。另一种工具是使用放射性药物2-氟-18-氟-2-脱氧-D-葡萄糖作为发射体的全身正电子断层扫描，因为它会在肿瘤内部积聚，尤其是黑色素瘤。我们报告了两例恶性黑色素瘤病例，其中计算机断层扫描和磁共振成像提示有内脏转移扩散。相比之下，全身正电子发射断层扫描显示无转移，这一点通过对疑似转移器官的组织学检查得到了证实。全身正电子发射断层扫描在临床黑色素瘤分期方面似乎具有很高的特异性和敏感性。
