Popova I A, Zabolotskaia I V, Balashov O I
State Research Center "Institute of Medical Biological Problems".
Aviakosm Ekolog Med. 1997;31(5):55-9.
Studies performed under conditions of a 120-day HDT in the female human subjects demonstrated that out of 20 biochemical parameters of the blood characterizing the carbohydrate and lipid exchange only 14 indices changed significantly during hypokinesia. As this takes place, the maximum number of changes was revealed with the help of the graded physical load test (GPL-test) and only in case of 9 indices the alterations were found at rest. Physical loads which have been used during HDT as the preventive measures had no effect only on insignificant part of metabolic shifts such as hypokinesia-associated increase of an activity of blood lactate dehydrogenase and relative content of phosphatidylcholine as well as an increased blood content of phosphates and decreased relative portion of phospholipids which also revealed with the aid of GPL-test. All other changes which have been revealed in HDT both at rest (increased blood level of triglycerides, lactate, relative content of free fatty acids, free cholesterine and sphingomyelin with augmented decrease in glucose concentration) as well as with the help of GPT-test (an increase of absolute blood content of free fatty acids with a decrease in their relative content; an increase of the relative content of total cholesterine with decreased portion of cholesterine ethers) have been stopped.
在女性人体受试者中进行的为期120天的卧床休息（HDT）条件下的研究表明，在表征碳水化合物和脂质交换的20项血液生化参数中，只有14项指标在运动减少期间发生了显著变化。在此过程中，通过分级体力负荷测试（GPL测试）发现了最大数量的变化，并且只有在9项指标的情况下，才在静息状态下发现了改变。在HDT期间作为预防措施使用的体力负荷仅对代谢变化的微不足道部分没有影响，例如与运动减少相关的血液乳酸脱氢酶活性增加、磷脂酰胆碱的相对含量以及磷酸盐血液含量增加和磷脂相对比例降低，这些也通过GPL测试得以揭示。在HDT中无论是在静息状态下（甘油三酯、乳酸的血液水平升高、游离脂肪酸、游离胆固醇和鞘磷脂的相对含量增加，同时葡萄糖浓度进一步降低）还是借助GPT测试所揭示的所有其他变化（游离脂肪酸的绝对血液含量增加，其相对含量降低；总胆固醇的相对含量增加，胆固醇醚的比例降低）都已停止。
