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[Combined effect of hypokinesia of various duration and gamma-radiation on central nervous system activity in rats].

作者信息

Shtemberg A S

机构信息

State Research Center "Institute of Medical Biological Problems", RF.

出版信息

Aviakosm Ekolog Med. 1997;31(5):70-5.

PMID:9508401
Abstract

There studied the effects of a combined effect of hypokinesia (HK) of various duration (7 and 30 days, corresponding to the stages of anxiety and resistance of general adaptation syndrome) and gamma-radiation dose of 3 Gy on the formation of differentiated motor-drinking conditioned reflex (CR) in the rats. It is demonstrated that the applied exposures lead to the various disorders of the higher nervous activity of the test animals: after 7-day hypokinesia in the behaviour there prevail the fear and emotional-vegetative components whereas following 30-day hypokinetic exposure there occurs some stimulation of the orientation-exploratory behaviour with concurrent enhancement of the inertness of nervous processes and the tendency to formation of stringent behavioural stereotypes slowing-down the conditioned reflex formation. A modifying effect of radiation counts only after 30-day hypokinesia and consists in the development of extra-limited inhibition (reaction of acquired helplessness) in the part of animals.

摘要

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