Rivera P, Pamos S, Cuquerella J, Ferrer L, Tomé A, Ortí E, Salvador I, Medina E
Servicio de Patología Digestiva, Hospital General Universitario de Valencia.
Gastroenterol Hepatol. 1997 Dec;20(10):484-9.
Collagenous colitis (CC) is a cause of chronic aqueous diarrhea with normal radiologic study and endoscopic appearance of the colonic mucosa. Histologically, it is defined by the presence of a thickened subepithelial collagenous band and inflammatory changes of the mucosa. The cause of CC is currently unknown, although several mechanisms have been proposed, such as an inflammatory, autoimmune, origin, disregulation in collagen synthesis, plasma vasculosis and a possible role of bacterial or drug toxins. The clinicopathological data of 12 patients (9 females and 3 males) with a mean age of 52.4 years diagnosed by histologic criteria are presented. Aqueous diarrhea was observed in all the patients with a mean number of 5.4 stools/day during a time period between 3 weeks and 10 years (mean, 14.7 months). In a 6 patients allergies and/or associated diseases, mainly rheumatologic diseases were found. Laboratory and endoscopic data were normal or unspecific, with colon biopsy being carried out in all the patients. Several treatments were tested with good response with sulphasalazine derivatives, corticoids, antibiotics, and mebeverine, with no solution to the diarrhea in 2 patients. A review of the literature is also provided.
胶原性结肠炎（CC）是慢性水样腹泻的一个病因，结肠黏膜的放射学检查和内镜检查表现正常。在组织学上，它的定义是存在上皮下胶原带增厚以及黏膜的炎症改变。尽管已经提出了几种机制，如炎症、自身免疫起源、胶原合成失调、血浆血管病变以及细菌或药物毒素可能起的作用，但CC的病因目前尚不清楚。本文介绍了12例经组织学标准诊断的患者（9例女性和3例男性）的临床病理资料，平均年龄52.4岁。所有患者均出现水样腹泻，在3周至10年（平均14.7个月）的时间段内，平均每天排便5.4次。在6例患者中发现了过敏和/或相关疾病，主要是风湿性疾病。实验室和内镜检查数据正常或无特异性，所有患者均进行了结肠活检。使用柳氮磺胺吡啶衍生物、皮质类固醇、抗生素和美贝维林进行了多种治疗，反应良好，但有2例患者的腹泻问题未得到解决。本文还提供了文献综述。
