Labbate L A, Grimes J, Hines A, Oleshansky M A, Arana G W
Medical University of South Carolina, Charleston, USA.
J Sex Marital Ther. 1998 Jan-Mar;24(1):3-12. doi: 10.1080/00926239808414663.
Serotonin reuptake inhibitor (SRI) antidepressants have been associated with sexual dysfunction, though there have been few prospective reports specifically examining this problem. The purpose of this study was to determine if three SRIs affected sexual function in patients with an anxiety disorder or major depressive disorder over a 3-month period. Sixty-one patients were evaluated for at least 2 months in a prospective study of the effects of fluoxetine, sertraline, and paroxetine on five aspects of sexual function: libido, erection/lubrication, orgasm quality, orgasm delay, and sexual frequency. Measurements were made at baseline and at each month on visual analog scales. For men and women, orgasm quality was lower and orgasm delay longer at Months 1, 2, and 3 compared with baseline (p < .001). Erection scores were lower over time (p < .02) but this change was less dramatic. Lubrication, libido, and sexual frequency were not appreciably changed over 3 months. Anorgasmia was significantly more common in women than men at Months 1 and 2. Orgasm appears to be a primary sexual function affected by SRIs.
血清素再摄取抑制剂（SRI）类抗抑郁药与性功能障碍有关，不过专门研究这一问题的前瞻性报告很少。本研究的目的是确定三种SRI类药物在3个月的时间里是否会影响焦虑症或重度抑郁症患者的性功能。在一项关于氟西汀、舍曲林和帕罗西汀对性功能五个方面（性欲、勃起/润滑、性高潮质量、性高潮延迟和性交频率）影响的前瞻性研究中，对61名患者进行了至少2个月的评估。在基线时以及每个月通过视觉模拟量表进行测量。与基线相比，男性和女性在第1、2和3个月时性高潮质量较低，性高潮延迟较长（p < 0.001）。勃起评分随时间降低（p < 0.02），但这种变化不太明显。在3个月里，润滑、性欲和性交频率没有明显变化。在第1和第2个月时，女性无高潮比男性明显更常见。性高潮似乎是受SRI类药物影响的主要性功能。
