唐氏综合征中与年龄相关的嵌合现象和多倍体现象。

Age-associated mosaicism and polyploidy in Down's syndrome.

作者信息

Borsatto B, Smith M de A, Garcez E M, Peres C A

机构信息

Departamento de Morfologia, Disciplina de Genética, UNIFESP-Escola Paulista de Medicina, Sao Paulo, Brazil.

出版信息

Mech Ageing Dev. 1998 Jan 12;100(1):77-83. doi: 10.1016/s0047-6374(97)00122-x.

DOI:10.1016/s0047-6374(97)00122-x

PMID:9509397

Abstract

Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 years. The polyploid data, together with previous work from this laboratory with non-DS subjects, suggest that this may be a useful indicator of aging in lymphocytes.

摘要

在54名年龄从0岁到48岁的唐氏综合征（DS）患者的短期外周血淋巴细胞培养物中，记录到21号染色体缺失细胞和多倍体细胞频率随年龄增长而增加。多倍体数据，连同本实验室之前对非唐氏综合征受试者的研究结果表明，这可能是淋巴细胞衰老的一个有用指标。