Grosswendt G, Baek W Y
Physikalisch-Technische Bundesanstalt, Braunschweig, Germany.
Phys Med Biol. 1998 Feb;43(2):325-37. doi: 10.1088/0031-9155/43/2/008.
The dosimetry of charged-particle beams is frequently performed by measuring the ionization yield produced in gas-filled ionization chambers and converting it into absorbed dose using the mean energy W expended in a gas per ion pair formed, or its differential value omega for the filling gas. Because of the increasing importance of proton therapy and the lack of accurate values of W and omega at high proton energies in particular, we investigated the ionization yield formation by protons in air and methane-based tissue-equivalent gas in the energy range up to 500 MeV. For this purpose, we analysed the available experimental values of W and omega and, in a second step, investigated the ionization-yield formation by protons as a function of their initial energy using an analytical method based on the Spencer-Fano equation in the framework of the continuous-slowing-down approximation. To estimate possible ionization losses which can be expected if the ionometric method is applied in the case of an incomplete secondary-electron equilibrium, a new analytical model has been developed which can be used to calculate the radial distribution of the ionization yield produced by secondary electrons around high-energy proton tracks.
带电粒子束的剂量测定通常是通过测量充气电离室中产生的电离产额,并使用每形成一个离子对在气体中消耗的平均能量W或其填充气体的微分值ω将其转换为吸收剂量来进行的。由于质子治疗的重要性日益增加,特别是在高质子能量下缺乏W和ω的准确值,我们研究了能量高达500 MeV范围内质子在空气和甲烷基组织等效气体中形成电离产额的情况。为此,我们分析了W和ω的现有实验值,第二步,使用基于连续慢化近似框架下的斯宾塞 - 法诺方程的分析方法,研究了质子形成电离产额与其初始能量的函数关系。为了估计在不完全二次电子平衡情况下应用离子测量方法时可能预期的电离损失,已经开发了一种新的分析模型,该模型可用于计算高能质子径迹周围二次电子产生的电离产额的径向分布。