Beringer J Y, Kerkhof P L
Kogarah Veterinary Hospital, NSW, Australia.
IEEE Trans Biomed Eng. 1998 Mar;45(3):365-71. doi: 10.1109/10.661161.
We studied volumetric characteristics of the ventricle in various hearts covering a wide (patho)physiological range, using the individual operating point at basal conditions. The aim of this analysis is to formulate a unifying relationship between volumetric parameters which will be applicable to cardiac ventricles regardless of underlying pathology. Analyzing our own measurements as well as additional data published elsewhere indicates that end-systolic volume (ESV) versus end-diastolic volume (EDV) yields a high linear population based correlation coefficient. This analytical expression can subsequently be used for the evaluation of clinically relevant derived indexes. For example, the new approach permits estimation of important physiological quantities such as stroke work and myocardial oxygen consumption, while isopleths and regions with equal ejection fraction can all be inscribed as linear relationships within a single graph. Based on statistical considerations, we demonstrate that in terms of correlation this new graphical representation is superior to the curve relating output (stroke volume) to input (preload) of the ventricle. We conclude that the ESV versus EDV representation facilitates insight into cardiac volumetric behavior and permits prediction of clinically relevant cardiodynamic effects, as produced by ventricular dimensional changes, for example induced by surgical or pharmacological intervention, or by the progression of cardiac disease.
我们使用基础条件下的个体工作点，研究了涵盖广泛（病理）生理范围的各种心脏中心室的容积特征。该分析的目的是建立容积参数之间的统一关系，这种关系将适用于任何潜在病理状态下的心脏心室。对我们自己的测量数据以及其他地方发表的额外数据进行分析表明，收缩末期容积（ESV）与舒张末期容积（EDV）之间呈现出基于群体的高线性相关系数。这个分析表达式随后可用于评估临床相关的派生指标。例如，新方法允许估计重要的生理量，如每搏功和心肌耗氧量，同时等容线和具有相同射血分数的区域都可以在单个图表中表示为线性关系。基于统计学考虑，我们证明，就相关性而言，这种新的图形表示优于心室输出（每搏量）与输入（前负荷）的曲线。我们得出结论，ESV与EDV的表示方式有助于深入了解心脏容积行为，并允许预测由心室尺寸变化产生的临床相关心脏动力学效应，例如手术或药物干预引起的变化，或心脏病进展导致的变化。
