Bang D, Chun Y S, Haam I B, Lee E S, Lee S
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1997 Dec;38(6):437-43. doi: 10.3349/ymj.1997.38.6.437.
Behçet's disease is a multisystem disorder that affects mainly young adults. Conflicting reports of the effects of pregnancy on the course of Behçet's disease have been reported. We studied 27 pregnant women with Behçet's disease using questionnaires, clinical examination, and laboratory tests. The condition of 18 patients worsened (66.7%) and 9 patients (33.3%) improved during pregnancy. In the deteriorated group, clinical exacerbation of Behçet's disease occurred most commonly during the first trimester (77.8%). They were primarily of the suspected or mucocutaneous type, while in the improved group, the majority of patients were of the incomplete and complete type, or the arthritic and ocular type. Of interest was the fact that all patients in the improved group showed exacerbations related to menstruation or postpartum, which indicated that progesterone may be the major hormone influencing the course of Behçet's disease.
白塞病是一种主要影响年轻成年人的多系统疾病。关于妊娠对白塞病病程影响的报道相互矛盾。我们通过问卷调查、临床检查和实验室检测对27例患有白塞病的孕妇进行了研究。18例患者（66.7%）病情恶化，9例患者（33.3%）在孕期病情改善。在病情恶化组中，白塞病的临床症状加重最常发生在孕早期（77.8%）。主要为疑似或黏膜皮肤型，而在病情改善组中，大多数患者为不完全型和完全型，或关节炎型和眼型。有趣的是，病情改善组中的所有患者在月经期间或产后均出现病情加重，这表明孕酮可能是影响白塞病病程的主要激素。
