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成年骨髓移植受者的呼吸道合胞病毒感染:短期雾化利巴韦林的有效治疗

Respiratory syncytial virus infection in adult BMT recipients: effective therapy with short duration nebulised ribavirin.

作者信息

McColl M D, Corser R B, Bremner J, Chopra R

机构信息

Department of Haematology, Royal Infirmary, Glasgow, UK.

出版信息

Bone Marrow Transplant. 1998 Feb;21(4):423-5. doi: 10.1038/sj.bmt.1701091.

DOI:10.1038/sj.bmt.1701091
PMID:9509980
Abstract

Respiratory syncytial virus (RSV), a common cause of both upper and lower respiratory tract infection (LRTI) in infants and children, is rarely described as an infective agent in adults. It has been reported in bone marrow transplant (BMT) recipients and patients with malignancy immunosuppressed by chemotherapy. Such reports are often associated with a high mortality. We report an outbreak of RSV infection which occurred predominantly in BMT recipients in which early investigation and institution of ribavirin therapy resulted in all patients making a full recovery.

摘要

呼吸道合胞病毒(RSV)是婴幼儿上、下呼吸道感染(LRTI)的常见病因,在成人中很少被描述为感染源。在骨髓移植(BMT)受者和因化疗而免疫抑制的恶性肿瘤患者中曾有相关报道。此类报道往往伴随着高死亡率。我们报告了一起主要发生在BMT受者中的RSV感染暴发,早期调查和使用利巴韦林治疗使所有患者完全康复。

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