Bovolenta P, Mallamaci A, Puelles L, Boncinelli E
Unidad de Neurobiologia del Desarollo, Instituto Cajal, Madrid, Spain.
Mech Dev. 1998 Jan;70(1-2):201-3. doi: 10.1016/s0925-4773(97)00183-4.
We describe the expression pattern of cSix3, a chick homologue of the murine Six3. cSix3 transcripts are expressed from presomitic stages in the most anterior portion of the neural plate. As the neural tube folds and the optic vesicles evaginate, cSix3 is expressed in the optic vesicle and the rostroventral forebrain. At later stages, cSix3 is found in most of the structures derived from the anterior neural plate, i.e. olfactory epithelium, septum, adenohypophysis, hypothalamus and preoptic areas. During eye development, cSix3 expression is first found in the entire optic vesicle and the overlying ectoderm but soon becomes restricted to the prospective neural retina and to the lens placode. In the developing neural retina, cSix3 is expressed in the entire undifferentiated neuroepithelium but is rapidly downregulated, first in the postmitotic photoreceptors and later in the majority of retinal ganglion cells.
我们描述了cSix3（小鼠Six3的鸡同源物）的表达模式。cSix3转录本在神经板最前端的体节形成前阶段就开始表达。随着神经管折叠和视泡外翻，cSix3在视泡和前腹侧前脑表达。在后期阶段，cSix3存在于源自前神经板的大多数结构中，即嗅觉上皮、隔膜、腺垂体、下丘脑和视前区。在眼睛发育过程中，cSix3表达首先在整个视泡和覆盖的外胚层中发现，但很快就局限于预期的神经视网膜和晶状体原基。在发育中的神经视网膜中，cSix3在整个未分化的神经上皮中表达，但很快被下调，首先是在有丝分裂后的光感受器中，随后在大多数视网膜神经节细胞中。
