文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Muller A, Maurin L, Bonne C

Laboratoire de Physiologie Cellulaire, Université Montpellier 1, France.

Gen Pharmacol. 1998 Mar;30(3):315-8. doi: 10.1016/s0306-3623(97)00362-5.

Glutamate (Glu) uptake in neurons and astrocytes is essential to prevent the persistence of excitotoxic levels of Glu in the synaptic cleft. 2. We investigated the effect of oxidative stress, which is also involved in ischemia-reperfusion, on the Glu transporter in isolated rat retinal cells. 3. Hydrogen peroxide (H2O2 3-300 microM) decreases the Na+-dependent Glu uptake. This effect is not related to a free radical production and is partly reversed by reducing agents, suggesting a transporter modulation by a redox-related event.

神经元和星形胶质细胞对谷氨酸（Glu）的摄取对于防止突触间隙中谷氨酸兴奋性毒性水平的持续存在至关重要。2. 我们研究了同样参与缺血再灌注的氧化应激对分离的大鼠视网膜细胞中谷氨酸转运体的影响。3. 过氧化氢（H2O2，3 - 300微摩尔）降低了钠依赖性谷氨酸摄取。这种作用与自由基产生无关，并且可被还原剂部分逆转，提示通过氧化还原相关事件对转运体进行调节。

Muller A, Maurin L, Bonne C

Laboratoire de Physiologie Cellulaire, Université Montpellier 1, France.

Gen Pharmacol. 1998 Mar;30(3):315-8. doi: 10.1016/s0306-3623(97)00362-5.

Glutamate (Glu) uptake in neurons and astrocytes is essential to prevent the persistence of excitotoxic levels of Glu in the synaptic cleft. 2. We investigated the effect of oxidative stress, which is also involved in ischemia-reperfusion, on the Glu transporter in isolated rat retinal cells. 3. Hydrogen peroxide (H2O2 3-300 microM) decreases the Na+-dependent Glu uptake. This effect is not related to a free radical production and is partly reversed by reducing agents, suggesting a transporter modulation by a redox-related event.

神经元和星形胶质细胞对谷氨酸（Glu）的摄取对于防止突触间隙中谷氨酸兴奋性毒性水平的持续存在至关重要。2. 我们研究了同样参与缺血再灌注的氧化应激对分离的大鼠视网膜细胞中谷氨酸转运体的影响。3. 过氧化氢（H2O2，3 - 300微摩尔）降低了钠依赖性谷氨酸摄取。这种作用与自由基产生无关，并且可被还原剂部分逆转，提示通过氧化还原相关事件对转运体进行调节。