Butkus D E, de Torrente A, Terman D S
Nephron. 1976;17(4):307-13. doi: 10.1159/000180735.
Acute renal failure (ARF) occurred concomitantly with the administration of gentamicin in combination with clindamycin in three patients in whom no other known predisposing cause of ARF could be demonstrated. The evidence for combined nephrotoxicity consisted of the temporal relationship between administration of the antibiotics and the development of ARF, and the prompt improvement in renal function upon cessation of therapy. Complete or partial recovery of renal function occured in all patients. Renal function should be carefully monitored in patients receiving this antibiotic combination.
三名患者在接受庆大霉素与克林霉素联合用药时并发急性肾衰竭（ARF），且未发现其他已知的ARF诱发因素。联合肾毒性的证据包括抗生素给药与ARF发生之间的时间关系，以及停药后肾功能迅速改善。所有患者的肾功能均实现了完全或部分恢复。接受这种抗生素联合治疗的患者应密切监测肾功能。
