Pongsa-Asawapaiboon A, Asavaritikrai P, Withyachumnarnkul B, Sumridthong A
Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand.
J Pineal Res. 1998 Mar;24(2):73-7. doi: 10.1111/j.1600-079x.1998.tb00369.x.
The effect of melatonin administration on nerve growth factor (NGF) was studied in the submandibular glands of adult Swiss male mice. Melatonin injection, at 1 microg daily for 30 days, resulted in an increase in the NGF content as detected by immunohistochemistry. The submandibular gland weight and the area of the granular convoluted tubules, which contained NGF, were also increased significantly. These effects were not observed when the dose of melatonin was increased to 10 and 50 microg daily. None of the melatonin treatments used influenced the weights or histology of the testes or seminal vesicles of the mice. The results suggest that melatonin, at physiological concentrations, directly regulates NGF synthesis in the mouse submandibular gland.
在成年瑞士雄性小鼠的颌下腺中研究了褪黑素给药对神经生长因子（NGF）的影响。每天注射1微克褪黑素，持续30天，通过免疫组织化学检测发现NGF含量增加。颌下腺重量以及含有NGF的颗粒曲管面积也显著增加。当褪黑素剂量增加到每天10微克和50微克时，未观察到这些效应。所使用的任何褪黑素处理均未影响小鼠睾丸或精囊的重量或组织学。结果表明，生理浓度的褪黑素直接调节小鼠颌下腺中NGF的合成。
