Aloe L, Cozzari C, Levi-Montalcini R
Brain Res. 1985 Apr 22;332(2):259-65. doi: 10.1016/0006-8993(85)90595-5.
The injection of a drug endowed with the property of stimulating alpha-adrenergic receptors, cyclocytidine (Cyclo-C), produces drastic depletion of NGF from the granular convoluted tubules (GCT) of the mouse submaxillary salivary gland and a marked NGF level increase in the bloodstream. The NGF discharged from the gland gains access to the blood. Histological studies, immunohistochemistry, in vitro biological assays and radioimmunoassays gave evidence for the growth response elicited by the endogenously released salivary NGF in intact and surgically axotomized sympathetic ganglia. These results suggest that the mouse salivary NGF displays a biological activity on its target sympathetic nerve cells.
注射具有刺激α-肾上腺素能受体特性的药物环胞苷（Cyclo-C），会导致小鼠颌下唾液腺颗粒曲管（GCT）中的神经生长因子（NGF）急剧减少，同时血液中的NGF水平显著升高。从腺体释放的NGF进入血液。组织学研究、免疫组织化学、体外生物学检测和放射免疫分析为内源性释放的唾液NGF在完整和手术切断轴突的交感神经节中引发的生长反应提供了证据。这些结果表明，小鼠唾液中的NGF对其靶交感神经细胞具有生物活性。
