Schwahn B, Mokov E, Scheidhauer K, Lettgen B, Schönau E
Department of Paediatrics, University Hospital Cologne, Germany.
Acta Paediatr. 1998 Jan;87(1):61-3. doi: 10.1080/08035259850157886.
The bone mineral density (BMD) of 14 children, adolescents, and adults with phenylketonuria (PKU) on dietary treatment (age 5-28 y; 6F, 8M) was investigated using peripheral quantitative computed tomography (pQCT) of the distal radius. BMD of total (TBMD) and spongy bone (SBMD) were compared to those of healthy gender-, age-, weight- and height-matched controls. We found a significant decrease of SBMD in patients with PKU while TBMD was only slightly decreased, reaching no statistical significance. These results indicate minor changes of BMD in patients with PKU under treatment, which are more accentuated in the trabecular bone compartment. One additional patient who was untreated until the pQCT investigation at the age of 10 y also showed markedly decreased SBMD and TBMD.
对14名接受饮食治疗的苯丙酮尿症（PKU）儿童、青少年和成人（年龄5 - 28岁；6名女性，8名男性），使用桡骨远端外周定量计算机断层扫描（pQCT）对其骨矿物质密度（BMD）进行了研究。将总体骨密度（TBMD）和松质骨骨密度（SBMD）与健康的、性别、年龄、体重和身高匹配的对照组进行比较。我们发现PKU患者的SBMD显著降低，而TBMD仅略有降低，无统计学意义。这些结果表明，接受治疗的PKU患者的BMD有轻微变化，在小梁骨部分更为明显。另外一名直到10岁进行pQCT检查时仍未接受治疗的患者，其SBMD和TBMD也显著降低。
