Caillot-Augusseau A, Lafage-Proust M H, Soler C, Pernod J, Dubois F, Alexandre C
Laboratoire de Biologie du Tissu Osseux, Faculté de Médecine, Saint Etienne, France.
Clin Chem. 1998 Mar;44(3):578-85.
Long-term spaceflights induce bone loss as a result of profound modifications of bone remodeling, the modalities of which remain unknown in humans. We measured intact parathyroid hormone (PTH) and serum calcium; for bone formation, serum concentrations of bone alkaline phosphatase (BAP), intact osteocalcin (iBGP), and type 1 procollagen propeptide (PICP); for resorption, urinary concentrations (normalized by creatinine) of procollagen C-telopeptide (CTX), free and bound deoxypyridinoline (F and B D-Pyr), and Pyr in a 36-year-old cosmonaut (RTO), before (days -180, -60, and -15), during (from days 10 to 178, n = 12), and after (days +7, +15, +25, and +90) a 180-day spaceflight, in another cosmonaut (ASW) before and after the flight. Flight PTH tended to decrease by 48% and postflight PTH increased by 98%. During the flight, BAP, iBGP, and PICP decreased by 27%, 38%, and 28% respectively in CM1, and increased by 54%, 35%, and 78% after the flight. F D-Pyr and CTX increased by 54% and 78% during the flight and decreased by 29% and 40% after the flight, respectively. We showed for the first time in humans that microgravity induced an uncoupling of bone remodeling between formation and resorption that could account for bone loss.
长期太空飞行会导致骨重塑发生深刻改变，进而引起骨质流失，而其具体机制在人类中尚不清楚。我们测量了一名36岁宇航员（RTO）在180天太空飞行前（-180天、-60天和-15天）、飞行期间（第10天至178天，n = 12）以及飞行后（+7天、+15天、+25天和+90天）的完整甲状旁腺激素（PTH）和血清钙；对于骨形成，测量了血清骨碱性磷酸酶（BAP）、完整骨钙素（iBGP）和I型前胶原肽（PICP）的浓度；对于骨吸收，测量了尿中（经肌酐标准化）前胶原C末端肽（CTX）、游离和结合脱氧吡啶啉（F和B D-Pyr）以及吡啶啉（Pyr）的浓度。另一名宇航员（ASW）在飞行前后也进行了测量。飞行期间PTH倾向于下降48%，飞行后PTH上升98%。在飞行期间，CM1中的BAP、iBGP和PICP分别下降了27%、38%和28%，飞行后分别上升了54%、35%和78%。F D-Pyr和CTX在飞行期间分别增加了54%和78%，飞行后分别下降了29%和40%。我们首次在人类中表明，微重力会导致骨形成和骨吸收之间的骨重塑解偶联，这可能是骨质流失的原因。
