Hennekens C H, Jesse M J, Klein B E, Gourley J E, Blumenthal S
Pediatrics. 1976 Aug;58(2):211-7.
Plasma cholesterol levels were obtained on 90 children of 39 men with premature myocardial infarction and 86 children of 39 healthy men. The mean cholesterol among children of affected men (195.1 mg/100 ml) was higher than among children of healthy men (176.6 mg/100 ml) (P equal to .009). Higher mean levels were demonstrable at each of nine age groups from 1 to 21 years(P equal to .004). Levels greater than 230 mg/100 ml were found in 16.7% of children of affected fathers and 4.7% of children of healthy fathers, a ratio of 3.6 to 1 (P equal to .01). These findings are compatible with the hypothesis that elevated childhood cholesterol level offers a mechanism whereby family history predicts coronary disease. A dip in cholesterol during adolescence, a finding that varies with population studied, was demonstratable among children of both affected healthy men.
对39名患有早发性心肌梗死男性的90名子女以及39名健康男性的86名子女进行了血浆胆固醇水平检测。患病男性子女的平均胆固醇水平（195.1毫克/100毫升）高于健康男性子女（176.6毫克/100毫升）（P值等于0.009）。在1至21岁的九个年龄组中，每个年龄组的平均水平均较高（P值等于0.004）。患病父亲的子女中16.7%的胆固醇水平高于230毫克/100毫升，健康父亲的子女中这一比例为4.7%，两者比例为3.6比1（P值等于0.01）。这些发现与以下假设相符：儿童期胆固醇水平升高提供了一种机制，通过该机制家族史可预测冠心病。在患病和健康男性的子女中均发现，青春期胆固醇水平会下降，这一发现因所研究的人群而异。
