Milner K K, Collins E E, Connors G R, Petty E M
Department of Psychiatry, The University of Michigan Medical Center, Ann Arbor 48109-0638, USA.
Am J Med Genet. 1998 Mar 5;76(2):111-9.
With recent advances in DNA technology, questions have arisen as to how this technology should be appropriately used. In this article, results obtained from a survey designed to elicit attitudes of college students to prenatal testing and gene therapy for human attributes and psychiatric conditions are reported. The eleven hypothetical disease phenotypes included schizophrenia, alcoholism, tendency toward violent behavior, attention deficit/hyperactivity disorder, depression requiring medical treatment, obesity, involvement in "dangerous" sports activities, homosexuality, borderline normal IQ (80-100), proportional short stature, and inability to detect perfect pitch. Most students supported prenatal genetic testing for psychiatric disorders and behavior that might result in harm to others (i.e., tendency towards violent behavior) and found prenatal genetic testing for human attributes less desirable. However, the lack of unilateral agreement or disagreement toward any one condition or attribute suggests the potential difficulties ahead in the quest for guidelines for the application of new technologies available to manipulate the human genome.
随着DNA技术的最新进展,关于如何恰当地使用这项技术的问题已经出现。本文报告了一项旨在了解大学生对人类特质和精神疾病的产前检测及基因治疗的态度的调查结果。这十一种假设的疾病表型包括精神分裂症、酗酒、暴力行为倾向、注意力缺陷/多动障碍、需要药物治疗的抑郁症、肥胖症、参与“危险”体育活动、同性恋、临界正常智商(80 - 100)、身材比例矮小以及无法识别绝对音高。大多数学生支持对可能对他人造成伤害的精神疾病和行为(即暴力行为倾向)进行产前基因检测,而认为对人类特质进行产前基因检测不太可取。然而,对于任何一种情况或特质缺乏单方面的同意或反对表明,在寻求应用可用于操纵人类基因组的新技术的指导方针方面,未来存在潜在困难。