Schultz R, Glaze D, Motil K, Hebert D, Percy A
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
J Child Neurol. 1998 Feb;13(2):71-4. doi: 10.1177/088307389801300205.
Growth failure is a major aspect of the developmental arrest in Rett syndrome. Small hands and feet have been reported anecdotally, but the pattern of hand and foot growth has not been studied rigorously. The aims of this study were to characterize the hand and foot growth of 28 girls with Rett syndrome and to examine the relationship between their hand or foot size and height. Median hand length deviated to the 5th percentile at 11 years of age whereas median foot length and height deviated below the 5th percentile at 5.5 years of age. After adjusting for height-age, a greater proportion of foot lengths than hand lengths was less than the 50th percentile. In conclusion, the rate of hand and foot growth of girls with Rett syndrome is slower than that of the normal female. Moreover, the rate of deceleration of foot, but not hand, growth relative to height growth is greater. Thus, many girls with Rett syndrome have "small" feet, but not hands, for their height.
生长发育迟缓是雷特综合征发育停滞的一个主要方面。虽然有轶事报道称雷特综合征患者手脚较小，但手脚生长模式尚未得到严格研究。本研究的目的是描述28名雷特综合征女孩的手脚生长情况，并研究她们的手脚大小与身高之间的关系。手部长度中位数在11岁时偏离至第5百分位数，而足部长度中位数和身高在5.5岁时偏离至第5百分位数以下。在根据身高年龄进行调整后，足部长度低于第50百分位数的比例高于手部长度。总之，雷特综合征女孩的手脚生长速度比正常女性慢。此外，相对于身高增长，足部而非手部生长减速的速度更大。因此，许多雷特综合征女孩相对于其身高而言脚“小”，但手并非如此。
